解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Since the discovery of the coelacanth, Latimeria chalumnae, more than 50 years ago, paleontologists and comparative morphologists have debated whether coelacanths or lungfishes, two groups of lobe-finned fishes, are the closest living relatives of land vertebrates (Tetrapoda). Previously, Meyer and Wilson (1990) deter...
journal_title:Journal of molecular evolution
pub_type: 杂志文章,评审
doi:10.1007/BF00183221
更新日期:1992-08-01 00:00:00
abstract::The specificity of interaction of amino acids with triplets in the acceptor helix stem of tRNA was investigated by means of a statistical analysis of 1400 tRNA sequences. The imprint of a prototypic genetic code at position 3-5 of the acceptor helix was detected, but only for those major amino acids, glycine, alanine,...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00160461
更新日期:1992-06-01 00:00:00
abstract::We have performed DNA-DNA hybridization experiments among several species of Drosophila using the evolutionarily conserved portion of the genome representing sequences coding for amino acids of proteins. This was done by using as tracer, radioactively labeled complementary DNA that was reverse transcribed from adult m...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00182390
更新日期:1992-02-01 00:00:00
abstract::Available molecular and biochemical data offer conflicting evidence for the origin of the cyanelle of Cyanophora paradoxa. We show that the similarity of cyanelle and green chloroplast sequences is probably a result of these two lineages independently developing the same pattern of directional nucleotide change (subst...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00182392
更新日期:1992-02-01 00:00:00
abstract::Two protein-coding regions (cytochrome b, ATPase 8, and part of ATPase 6) from mitochondrial DNA of Cottus kessleri, Cottocomephorus grewingki, and Cottocomephorus inermis--Baikalian endemic sculpins--were amplified via polymerase chain reaction, and sequenced. Two novel primers--L8352 (5'-TAAAGATTGGTGAC TCCCAACCACC) ...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00163855
更新日期:1992-01-01 00:00:00
abstract::A 6.0-kb DNA fragment from Gorilla gorilla including the 5' part of the beta-globin gene and about 4.5 kb of its upstream flanking region was cloned and sequenced. The sequence was compared to the human, chimpanzee, and macaque delta-beta intergenic region. This analysis reveals four tandemly repeated sequences (RS), ...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00163849
更新日期:1992-01-01 00:00:00
abstract::The transposable element mariner occurs widely in the melanogaster species group of Drosophila. However, in drosophilids outside of the melanogaster species group, sequences showing strong DNA hybridization with mariner are found only in the genus Zaprionus. The mariner sequence obtained from Zaprionus tuberculatus is...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02102804
更新日期:1991-12-01 00:00:00
abstract::Analysis of mitochondrial DNAs (mtDNAs) from parthenogenetic lizards of the Heteronotia binoei complex with restriction enzymes revealed an approximately 5-kb addition present in all 77 individuals. Cleavage site mapping suggested the presence of a direct tandem duplication spanning the 16S and 12S rRNA genes, the con...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02103135
更新日期:1991-11-01 00:00:00
abstract::This study dealt with the ability of non-denaturing gel electrophoresis to separate iso-1-cytochrome c with single amino acid replacements isolated from revertants of various cyc1 nonsense mutants of the yeast Saccharomyces cerevisiae. A total of 28 different iso-1-cytochromes c with single amino acid substitutions of...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02102869
更新日期:1991-10-01 00:00:00
abstract::The gene (fus) coding for elongation factor G (EF-G) of the extremely thermophilic eubacterium Thermotoga maritima was identified and sequenced. The EF-G coding sequence (2046 bp) was found to lie in an operon-like structure between the ribosomal protein S7 gene (rpsG) and the elongation factor Tu (EF-Tu) gene (tuf). ...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02193628
更新日期:1991-08-01 00:00:00
abstract::The present work represents the first attempt to study in greater detail previously proposed compositional correlations in genomes, based on a body of additional data relating to gene localizations as well as to extended flanking sequences extracted from gene banks. We have investigated the correlations that exist bet...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02102651
更新日期:1991-06-01 00:00:00
abstract::The efficiency of obtaining the correct tree by the maximum likelihood method (Felsenstein 1981) for inferring trees from DNA sequence data was compared with trees obtained by distance methods. It was shown that the maximum likelihood method is superior to distance methods in the efficiency particularly when the evolu...
journal_title:Journal of molecular evolution
pub_type: 评论,杂志文章
doi:10.1007/BF02101285
更新日期:1991-05-01 00:00:00
abstract::Single-fly polymerase chain reaction amplification and direct DNA sequencing revealed high levels of length polymorphism in the threonine-glycine encoding repeat region of the period (per) gene in natural populations of Drosophila melanogaster. DNA comparison of two alleles of identical lengths gave a high number of s...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02342746
更新日期:1991-03-01 00:00:00
abstract::In the traditional concept for the origin of life as proposed by Oparin and Haldane in the 1920s, prebiotic reactants became slowly concentrated in the primordial oceans and life evolved slowly from a series of highly protracted chemical reactions during the first billion years of Earth's history. However, chemical e...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02102187
更新日期:1991-01-01 00:00:00
abstract::The amino acid sequences of the largest subunits of the RNA polymerases I, II, and III from eukaryotes were compared with those of archaebacterial and eubacterial homologs, and their evolutionary relationships were analyzed in detail by a recently developed tree-making method, the likelihood method of protein phylogen...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02099931
更新日期:1991-01-01 00:00:00
abstract::In the maximum likelihood (ML) method for estimating a molecular phylogenetic tree, the pattern of nucleotide substitutions for computing likelihood values is assumed to be simpler than that of the actual evolutionary process, simply because the process, considered to be quite devious, is unknown. The problem, however...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02099932
更新日期:1991-01-01 00:00:00
abstract::Transbilayer diffusion of Mn2+ ions occurred in liposomes formed from dipalmitoyl-phosphatidylcholine or egg-yolk phosphatidylcholine and egg-yolk phosphatidate (molar ratio 2:1) containing DNA and DNase I within their aqueous compartments. Cation diffusion was demonstrated by the hydrolytic activity of DNase I, activ...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02102071
更新日期:1990-12-01 00:00:00
abstract::Autosomal chorion genes s18, s15, and s19 are shown to diverge at extremely rapid rates in closely related taxa of Hawaiian Drosophila. Their nucleotide divergence rates are at least as fast as those of intergenic regions that are known to evolve more extensively between distantly related species. Their amino acid div...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02106055
更新日期:1990-11-01 00:00:00
abstract::In this paper we present an iterative character weighting method for the construction of phyletic trees. An initial tree is used to calculate the character weights, which are the number of mutations normalized so that the possible range is corrected for. The weights obtained are used to adjust the tree; this process i...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02101127
更新日期:1990-10-01 00:00:00
abstract::Mitochondrial DNA (mtDNA) restriction site maps for nine species of the Drosophila obscura subgroup and for Drosophila melanogaster were established. Taking into account all restriction enzymes (12) and strains (45) analyzed, a total of 105 different sites were detected, which corresponds to a sample of 3.49% of the m...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02109481
更新日期:1990-08-01 00:00:00
abstract::We describe the structure of a gene expressed in the salivary gland cells of the dipteran Chironomus tentans and show that it encodes 1 of the approximately 15 secretory proteins exported by the gland cells. This sp115,140 gene consists of approximately 65 copies of a 42-bp sequence in a central uninterrupted core blo...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02101791
更新日期:1990-07-01 00:00:00
abstract::We have determined the nucleotide sequence of the 26S large subunit (LSU) rRNA genes for two Tetrahymena species, T. thermophila and T. pyriformis. The inferred rRNA sequences are presented in their most probable secondary structures based on compensatory mutations, energy, and conservation criteria. The majority of t...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02101107
更新日期:1990-06-01 00:00:00
abstract::The weight-averaged observed/expected dinucleotide frequencies for the sum total of the coding regions of five Toxoplasma genes were compared with the same parameters previously determined for the coding regions of 21 Plasmodium genes. In addition, codon usage in the five Toxoplasma genes was compared with that in the...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02101892
更新日期:1990-04-01 00:00:00
abstract::Previous observations have indicated that Drosophila DNA contains a component that evolves so rapidly that it fails to hybridize between the DNAs of sibling species. To establish the reality of this component and study its properties, the fraction (about 20%) of Drosophila simulans (Dsim) DNA that fails to hybridize t...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02099998
更新日期:1990-03-01 00:00:00
abstract::Four genes in the P450 IID gene subfamily were isolated from Sprague-Dawley rat lambda EMBL 3 and Charon 4A genomic libraries and completely sequenced. Their transcription start sites were determined by primer extension analysis. The four genes designated IID2, IID3, IID4, and IID5 span 4036, 4371, 4678, and 4567 bp, ...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02099942
更新日期:1990-02-01 00:00:00
abstract::The finding that ribozymes can catalyze RNA chain elongation has led to the proposal that an early self-replicating system could have consisted of RNA alone. In such a chain elongation reaction, the Tetrahymena ribozyme was found to select 3',5'-linked substrates from a pool that contained a large molar excess of 2',5...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02602919
更新日期:1989-12-01 00:00:00
abstract::Three measures of sequence dissimilarity have been compared on a computer-generated model system in which substitutions in random sequences were made at randomly selected sites and the replacement character was chosen at random from the set of characters different from the original occupant of the site. The three meas...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02602925
更新日期:1989-12-01 00:00:00
abstract::A few years ago we presented a stationary Markov model of gene evolution according to which only homologous genes from not too divergent species obeying the condition of being stationary may behave as reliable molecular clocks. A compartmentalized model of the nuclear genome in which the genes are distributed in compa...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02602910
更新日期:1989-11-01 00:00:00
abstract::We report the sequence of A/B.L1, a tightly linked pair of genes from the A and B chorion families in Bombyx mori. Comparison with the previously characterized A/B.L11 and A/B.L12 pairs from the same species reveals moderate sequence divergence, which is clearly nonuniform. Although the average divergence of A/B.L12 f...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02602909
更新日期:1989-11-01 00:00:00
abstract::The level reached by the optimization of the polarity distances during the evolution of the genetic code was investigated. The results, although not conclusive, indicate that this optimization level is higher than the data reported in the literature. The results seem compatible with the reaching of an evolutionary min...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02103616
更新日期:1989-10-01 00:00:00
abstract::The genome of Glycine max (L.) Merr. cv. "Dare" contains a chlorophyll a/b binding (Cab) protein gene family consisting of 10 genes. The primary structures of two linked Cab genes (Cab 4 and Cab 5) were determined. A comparison of the nucleic acid and predicted amino acid sequences of Cab 4 and Cab 5 revealed a high d...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02100210
更新日期:1989-09-01 00:00:00
abstract::By a chromosome walking strategy the DNA region from Methanococcus vannielii flanking the genes for protein synthesis elongation factor (EF) 1 alpha and EF-2 was cloned and sequenced. A gene organization of 5' - beta' - open reading frame (ORF) 1 - ORF2 - S12 - S7 - EF-2 - EF-1 alpha - S10 - ORF3 - ORF4 - 3' was found...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02106178
更新日期:1989-07-01 00:00:00
abstract::The relationships of genome organization among elongated (rod-shaped and filamentous) plant viruses have been analyzed. Sequences in coding and noncoding regions of barley stripe mosaic virus (BSMV) RNAs 1, 2, and 3 were compared with those of the monopartite RNA genomes of potato virus X (PVX), white clover mosaic vi...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02106181
更新日期:1989-07-01 00:00:00
abstract::Males of three inbred lines of Drosophila melanogaster were heat-shocked 90 min at 37 degrees C. The progenies from treated and untreated males mated with untreated females of the same line were checked for their chromosomal insertion patterns of various mobile elements by either in situ hybridization or Southern blot...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02603073
更新日期:1989-05-01 00:00:00
abstract::One of the pupal cuticle protein (PCP) genes has been found within an intron of a Drosophila housekeeping gene (the Gart locus) that encodes three enzymes involved in the purine pathway. This intronic gene has been described as a gene within a gene, and the gene is now called a "nested" gene. Because the intronic PCP ...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02603074
更新日期:1989-05-01 00:00:00
abstract::The organization of histone gene clusters of the duck Cairina moschata was studied in the DNA inserts of two recombinant phage that overlap and feature identical histone gene arrangements but differ in sequence details and in the extent of repetition of an AT-rich motif in one of the nontranscribed spacer regions. The...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02102477
更新日期:1989-03-01 00:00:00
abstract::DNA clones have been isolated that span the complete mitochondrial (mt) genome of the dolphin, Cephalorhynchus commersonii. Hybridization experiments with purified primate mtDNA probes have established that there is close resemblance in the general organization of the dolphin mt genome and the terrestrial mammalian mt...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02143495
更新日期:1988-12-01 00:00:00
abstract::We have cloned and sequenced a protamine gene from the chum salmon (Oncorhynchus keta). This gene sequence is highly homologous to one found in the rainbow trout (Salmo gairdneri), including the conservation of two structurally different repetitive elements. One of these repeats resembles a nonviral retroposon and the...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02099725
更新日期:1988-01-01 00:00:00
abstract::Polymerization of various nucleoside-5'-phosphorimidazolides has been conducted in neutral aqueous solution using divalent metal ions as catalysts. Oligonucleotide formation took place from each of the ribonucleoside-5'-phosphorimidazolides, ImpC, ImpU, ImpA, ImpG, and ImpI. The yields and distributions of the resulti...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02100072
更新日期:1988-01-01 00:00:00
abstract::A new type of repeat unit was isolated from Balbiani ring 1 of Chironomus pallidivittatus and designated BR1 beta repeat. It consists of a constant and a subrepeated part, like previously described units belonging to the core blocks of the BR genes. The subrepeated part contains 10-codon subrepeats with an arrangement...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02101191
更新日期:1988-01-01 00:00:00